Pharmacology
Alprazolam works by binding to the GABA-benzodiazepine receptor complex, increasing inhibitory neurotransmission. Higher doses intensify its sedative and muscle-relaxant effects.
Dosage
Initial dosing is typically 0.25–0.5 mg taken three times daily. Dosage may be increased gradually every 3–4 days, with a maximum daily dose of 4 mg. Dose tapering should be gradual to avoid withdrawal symptoms. Elderly or hepatic-impaired patients should start with lower doses.
Use in Special Populations
Safety in individuals under 18 years of age has not been established.
Pregnancy & Breastfeeding
Alprazolam is a Category D drug and should not be used during pregnancy. It may pass into breast milk; breastfeeding is discouraged during treatment.
Overdose
Overdose symptoms include severe drowsiness, confusion, impaired coordination, and coma. Immediate medical intervention is required.
Storage
Store below 30°C in a dry, dark place. Keep out of reach of children.